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So there is plenty of evidence showing that Metformin and Vitamin B12 deficiency is a problem, especially with long term use of Metformin and this is a drug that is usually taken “forever” once it is prescribed Metformin And Vitamin B12 Deficiency – The Solution The first thing to do is to get your vitamin B12 levels tested so that you have a baseline reading, don’t follow the reference range but make sure your levels are over 400 as a minimum